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University Study Shows “Protective Action” of OptiMSM® on Articular Cartilage

The first mechanism of action study suggests that OptiMSM may protect articular cartilage and reduce inflammation in early osteoarthritis.

Findings Presented at the OsteoArthritis Research Society International (OARSI) Conference

Abstract to be Published in Peer-Reviewed Osteoarthritis and Cartilage Journal

San Diego, CA, December 6, 2007—Researchers from the University of California, San Diego presented new research findings today at the 2007 World Congress on Osteoarthritis in Ft. Lauderdale, providing the first evidence of how methylsulfonylmethane (MSM) may protect articular cartilage and reduce inflammation in osteoarthritis. The form of MSM used in the study, OptiMSM was provided by Bergstrom Nutrition, Vancouver WA .

The study examined the effect of OptiMSM on healthy and osteoarthritic articular cartilage from post mortem human knees. Researchers focused on the expression of specific genes related to cartilage degradation and markers of inflammation, called cytokines. Overexpression of these genes and their related proteins are associated with the progression of osteoarthritis.

The study showed reduced expression of genes for pro-inflammatory cytokines and cartilage degrading enzymes. “It suggests that MSM acts as a barrier, shielding cartilage in early stages of osteoarthritis from further degeneration from inflammatory cytokines and cartilage degrading enzymes,” says cartilage biology expert and lead researcher, David Amiel, Ph.D., Connective Tissue Biochemistry, Department of Orthopaedic Surgery, University of California San Diego. The research team also included Yasushi Oshima, M.D., Ph.D. “This initial exploratory study aligns with the clinical evidence previously published by Kim et al. in Osteoarthritis and Cartilage Journal, March 2006, both on OptiMSM,” Dr. Amiel added. NOTE TO EDITOR: Copies of abstract and interviews with principal investigators available upon request.

The researchers point out that, while the in vitro study is significant in revealing the protective action of OptiMSM, additional investigations are required to specify the optimum dose concentration for use in supplements by humans. The generally recommended dosage is 1,500 to 6,000 mg of MSM per day. More research is being planned for 2008. Abstracts of research available at www.msmguide.com.

About Bergstrom Nutrition Bergstrom Nutrition based in Vancouver, Washington, introduced MSM to the human market in 1989. Its flagship product, OptiMSM, is the only MSM backed by U.S. published clinical research. OptiMSM is made entirely in the U.S., in the only NPA cGMP facility solely dedicated to MSM manufacturing. OptiMSM is available in 18 countries and can be found in brands such as OsteoBiFlex, MoveFree, Nature’s Way, Jarrow Formulas, Nature’s Sunshine, Solaray, Natural Factors, and Vitamin Shoppe. For information visit Bergstrom Nutrition



Arthritis sufferers are daily bombarded with new, better, more exciting treatments. Try Enbrel! Try Humira! Miracle drugs!Get your NSAIDS! Get your DMARDS! Pump more chemicals into your system. Side effects? What sideeffects? You have a choice; accept the side effects or get sicker and sicker.

In order to allay our fears, the drug companies publish the results of their clinical tests. This double blind study proved that that lethal chemical reduced your swelling more than another, equally lethal chemical.

Do they think they're playing with babies? Yes. That's exactly what they think. Arthritis is such a horrible, debilitating disease that we'll try anything to reduce the symptoms. And that's exactly what these awful drugs do. They reduce the symptoms, temporarily. As the symptoms creep back, your rheumatologist increases the drug or experiments with other lethal concoctions to reduce your swelling or pain. We're told there's NOcure for arthritis. We're told that no one knows the cause. Really! Almopst forty years ago we sent men to play golf on the moon. But we can't pin point even one cause for this crippling disease?

It's time for a reality check. The drug companies will continue to pump out really expensive chemicals, ostensibly helpful. Our doctors will continue to serve up the concoctions fed to them by the drug companies.Unless we refuse to go along with this travesty. We don't need a revolution. We don't even need to take on our doctors or the drug companies. We only need to pool our resources and conduct our own quiet experiments.

We need to experiment with our habits. Just take one aspect of our life and alter it for one month. For example, are you a heavy coffee drinker? I'm pretty well wired to the ceiling by mid-day. Cut coffee from your diet for one month. Document any changes to your system resultingfrom this. You may, of course, suffer withdrawal symptoms but you may also experience a very welcome reduction in arthritic pain and swelling.

That's just one suggestion. We have lots more. Feed-back from our brave experimenters will eventually allow us to make real recommendations. The revolution has started!

Patricia R. Moynihan is the Irish lawyer who founded Dealon Bracelets Inc. in 1976. She is a noted writer and speaker on alternative health and internet marketing. You can reach her at her web site Dealon Bracelets



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